voxelizer 4  (MathWorks Inc)

Journal: Psychiatry research

Article Title: Cingulate and thalamic metabolites in obsessive-compulsive disorder

doi: 10.1016/j.pscychresns.2016.05.005

Figure Lengend Snippet: [A] sample MR spectrum from left pregenual anterior cingulate cortex (pACC) with principal resonances for N-acetyl-aspartate+N-acetyl-aspartylyglutamate (NAA+NAAG = tNAA), glutamate+glutamine (Glu+Gln = Glx), creatine+phosphocreatine (Cr), choline-compounds (Cho), and myo-inositol (mI). [B] parasagittal, coronal and axial-oblique T1w MRI sections showing position of MRS acquisition volume (“voxel”) for left pACC. [C] the same for left anterior middle cingulate cortex (aMCC) voxel. [D] The same for left thalamus voxel. Voxels were acquired at homologous sites in the right cerebral hemisphere.

Article Snippet: Two more recent pediatric studies, one using a 3-cc voxel straddling pACC/aMCC ( Ortiz et al., 2015 ), the other using 4-cc bilateral voxels in pACC ( Starck et al., 2008 ), found no difference in Glx between patients and controls.

Techniques:

Journal: Psychiatry research

Article Title: Cingulate and thalamic metabolites in obsessive-compulsive disorder

doi: 10.1016/j.pscychresns.2016.05.005

Figure Lengend Snippet: Elevated levels of glutamate+glutamine measured by magnetic resonance spectroscopy (MRS) in pregenual anterior cingulate cortex (pACC) of OCD patients relative to healthy controls. Levels did not differ significantly for patients treated and not-treated with serotonin reuptake inhibitors. (SRIs). IU=Institutional Units

Article Snippet: Two more recent pediatric studies, one using a 3-cc voxel straddling pACC/aMCC ( Ortiz et al., 2015 ), the other using 4-cc bilateral voxels in pACC ( Starck et al., 2008 ), found no difference in Glx between patients and controls.

Techniques: Spectroscopy

Journal: Psychiatry research

Article Title: Cingulate and thalamic metabolites in obsessive-compulsive disorder

doi: 10.1016/j.pscychresns.2016.05.005

Figure Lengend Snippet: MRS Cr and Cho drop with increasing OCD symptoms; Cr rises with increasing functioning. pACC Cr and Cho levels in OCD are close to normal means (horizontal solid blue bars), yet vary significantly with psychiatric symptoms. Symptoms themselves are outside normal ranges, indicated by vertical dashed blue bars marking measured control (GAS) or standard subclinical (YBOCS) ranges. [A] Cr and [B] Cho in pACC drop with increasing obsessive-compulsive symptoms. Cr in pACC [C] and thalamus [D] rises with increasing global functioning. (Not shown) Cr and Cho in pregenual cingulate and also anterior middle cingulate similarly drop with increasing depressive symptoms. For abbreviations, see Figs. 1–2.

Article Snippet: Two more recent pediatric studies, one using a 3-cc voxel straddling pACC/aMCC ( Ortiz et al., 2015 ), the other using 4-cc bilateral voxels in pACC ( Starck et al., 2008 ), found no difference in Glx between patients and controls.

Techniques: Control